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TBC1D23 Antikörper (Internal Region)

TBC1D23 Reaktivität: Human, Maus, Ratte WB, IHC, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265479
  • Target Alle TBC1D23 Produkte
    TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
    Bindungsspezifität
    • 4
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 9
    Kaninchen
    Klonalität
    • 9
    Polyklonal
    Konjugat
    • 6
    • 1
    • 1
    • 1
    Dieser TBC1D23 Antikörper ist unkonjugiert
    Applikation
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    TBC1D23 Antibody detects endogenous levels of total TBC1D23.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TBC1D23, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
    Andere Bezeichnung
    TBC1D23 (TBC1D23 Produkte)
    Synonyme
    RGD1307925 antikoerper, NS4ATP1 antikoerper, 4930451A13Rik antikoerper, AU015720 antikoerper, AU043671 antikoerper, AU043778 antikoerper, D030022P07Rik antikoerper, W51689 antikoerper, zgc:63756 antikoerper, TBC1 domain family, member 23 antikoerper, TBC1 domain family member 23 antikoerper, Tbc1d23 antikoerper, TBC1D23 antikoerper, tbc1d23 antikoerper
    Hintergrund

    Description: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).

    Gene: TBC1D23

    Molekulargewicht
    78 kDa
    Gen-ID
    55773
    UniProt
    Q9NUY8
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