TERT Antikörper (Internal Region)
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- Target Alle TERT Antikörper anzeigen
- TERT (Telomerase Reverse Transcriptase (TERT))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TERT Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- TERT Antibody detects endogenous levels of total TERT.
- Homologie
- Pig,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TERT, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product TERT Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation." in: Gut, Vol. 66, Issue 1, pp. 31-42, (2017) (PubMed).
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hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation." in: Gut, Vol. 66, Issue 1, pp. 31-42, (2017) (PubMed).
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- Target
- TERT (Telomerase Reverse Transcriptase (TERT))
- Andere Bezeichnung
- TERT (TERT Produkte)
- Synonyme
- CMM9 antikoerper, DKCA2 antikoerper, DKCB4 antikoerper, EST2 antikoerper, PFBMFT1 antikoerper, TCS1 antikoerper, TP2 antikoerper, TRT antikoerper, hEST2 antikoerper, hTRT antikoerper, chTERT antikoerper, Tert antikoerper, ATTERT antikoerper, F5E19.190 antikoerper, F5E19_190 antikoerper, telomerase reverse transcriptase antikoerper, tert antikoerper, TR antikoerper, est2 antikoerper, tcs1 antikoerper, telomerase antikoerper, tert-A antikoerper, tp2 antikoerper, trt antikoerper, xTERT antikoerper, telomerase reverse transcriptase antikoerper, Telomerase Reverse Transcriptase antikoerper, Tertp antikoerper, Telomerase catalytic subunit antikoerper, telomerase reverse transcriptase L homeolog antikoerper, TERT antikoerper, trt-1 antikoerper, Tert antikoerper, tert antikoerper, CMU_003490 antikoerper, VDBG_04487 antikoerper, GL50803_16225 antikoerper, tert.L antikoerper
- Hintergrund
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Description: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
Gene: TERT
- Molekulargewicht
- 127 kDa
- Gen-ID
- 7015
- UniProt
- O14746
- Pathways
- Telomere Maintenance
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