THOC1 Antikörper (C-Term)

Produktnummer ABIN6265557

Produktdetails anti-THOC1 Antikörper

Target: THOC1 (THO Complex 1 (THOC1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THOC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: THOC1 Antibody detects endogenous levels of total THOC1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human THOC1, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu THOC1

Target: THOC1 (THO Complex 1 (THOC1))

Andere Bezeichnung: THOC1 (THOC1 Produkte)

Synonyme: p84 antikoerper, MGC114861 antikoerper, Tho1 antikoerper, THOC1 antikoerper, Hpr1 antikoerper, HPR1 antikoerper, P84 antikoerper, P84N5 antikoerper, 3110002N20Rik antikoerper, AW107452 antikoerper, NMP-84 antikoerper, LRRGT00070 antikoerper, THO complex 1 antikoerper, THO complex 1 protein L homeolog antikoerper, THO complex subunit 1 antikoerper, THO complex 1 protein antikoerper, thoc1 antikoerper, thoc1.L antikoerper, THOC1 antikoerper, LOC100123388 antikoerper, Thoc1 antikoerper

Hintergrund:

Description: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.

Gene: THOC1

Molekulargewicht: 76 kDa

Gen-ID: 9984

UniProt: Q96FV9