THO Complex 5 Antikörper (Internal Region)

Produktnummer ABIN6265558

Produktdetails anti-THO Complex 5 Antikörper

Target: THO Complex 5 (THOC5)

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THO Complex 5 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: THOC5 Antibody detects endogenous levels of total THOC5.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human THOC5, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu THO Complex 5

Target: THO Complex 5 (THOC5)

Andere Bezeichnung: THOC5 (THOC5 Produkte)

Synonyme: C22orf19 antikoerper, Fmip antikoerper, PK1.3 antikoerper, fSAP79 antikoerper, 1700060C24Rik antikoerper, A430085L24Rik antikoerper, Sgk2 antikoerper, fc54b09 antikoerper, wu:fc54b09 antikoerper, zgc:56190 antikoerper, zgc:76912 antikoerper, THOC5 antikoerper, fmip antikoerper, thoc5 antikoerper, thoc5-a antikoerper, thoc5-b antikoerper, THO complex 5 antikoerper, THO complex 5 S homeolog antikoerper, THO complex 5 L homeolog antikoerper, THOC5 antikoerper, Thoc5 antikoerper, thoc5 antikoerper, thoc5.S antikoerper, thoc5.L antikoerper

Hintergrund:

Description: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes.

Gene: THOC5

Molekulargewicht: 79 kDa

Gen-ID: 8563

UniProt: Q13769