PAR1 Antikörper (N-Term)

Produktnummer ABIN6265563

Produktdetails anti-PAR1 Antikörper

Target: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: Thrombin Receptor Antibody detects endogenous levels of total Thrombin Receptor.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Thrombin Receptor, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Referenzen für anti-PAR1 Antikörper (ABIN6265563)

Zhao, Zheng, Liu, Luo, Wu, Liu, Zou: "Inhibiting trophoblast PAR-1 overexpression suppresses sFlt-1-induced anti-angiogenesis and abnormal vascular remodeling: a possible therapeutic approach for preeclampsia." in: Molecular human reproduction, Vol. 24, Issue 3, pp. 158-169, (2018) (PubMed).

Zhong, Chen, Zhang, Xiao, Qin, Gu, Sun, Liu, Jing, Hu, Zhang, Zhou, Sun, Yang: "Doxycycline directly targets PAR1 to suppress tumor progression." in: Oncotarget, Vol. 8, Issue 10, pp. 16829-16842, (2017) (PubMed).

Details zu PAR1

Target: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Andere Bezeichnung: F2R (F2R Produkte)

Synonyme: CF2R antikoerper, HTR antikoerper, PAR-1 antikoerper, PAR1 antikoerper, TR antikoerper, Par1 antikoerper, TRGPC antikoerper, AI482343 antikoerper, Cf2r antikoerper, ThrR antikoerper, Par-1 antikoerper, f2r-a antikoerper, par1 antikoerper, coagulation factor II thrombin receptor antikoerper, coagulation factor II (thrombin) receptor antikoerper, coagulation factor 2 (thrombin) receptor L homeolog antikoerper, F2R antikoerper, F2r antikoerper, f2r.L antikoerper

Hintergrund:

Description: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Gene: F2R

Molekulargewicht: 48kDa

Gen-ID: 2149

UniProt: P25116

Pathways: Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus