TIMELESS Antikörper (C-Term)

Produktnummer ABIN6265574

Produktdetails anti-TIMELESS Antikörper

Target: TIMELESS (Timeless Homolog (TIMELESS))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMELESS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: TIMELESS Antibody detects endogenous levels of total TIMELESS.

Homologie: Pig

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TIMELESS, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu TIMELESS

Target: TIMELESS (Timeless Homolog (TIMELESS))

Andere Bezeichnung: TIMELESS (TIMELESS Produkte)

Synonyme: TIM antikoerper, TIM1 antikoerper, hTIM antikoerper, C77407 antikoerper, Debt69 antikoerper, tim antikoerper, CG3234 antikoerper, Dmel\\CG3234 antikoerper, Ritsu antikoerper, Tim antikoerper, dTIM antikoerper, dTim antikoerper, dtim antikoerper, mel_tim antikoerper, rit antikoerper, tim1 antikoerper, XTimeless1 antikoerper, timeless antikoerper, timelessb antikoerper, TIMELESS antikoerper, MXC20.14 antikoerper, MXC20_14 antikoerper, htim antikoerper, im:6903167 antikoerper, wu:fa95g04 antikoerper, wu:fd23d07 antikoerper, timeless circadian regulator antikoerper, timeless circadian clock 1 antikoerper, timeless antikoerper, timeless circadian clock antikoerper, timeless circadian clock S homeolog antikoerper, timeless family protein antikoerper, TIMELESS antikoerper, Timeless antikoerper, tim antikoerper, timeless.S antikoerper, Tim antikoerper, ATIM antikoerper, timeless antikoerper, LOC100328917 antikoerper

Hintergrund:

Description: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

Gene: TIMELESS

Molekulargewicht: 139 kDa

Gen-ID: 8914

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism