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TOP1MT Antikörper (Internal Region)

TOP1MT Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265672
  • Target Alle TOP1MT Antikörper anzeigen
    TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))
    Bindungsspezifität
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 28
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 18
    • 12
    Kaninchen
    Klonalität
    • 16
    • 14
    Polyklonal
    Konjugat
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TOP1MT Antikörper ist unkonjugiert
    Applikation
    • 11
    • 10
    • 10
    • 9
    • 7
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA
    Spezifität
    TOP1MT Antibody detects endogenous levels of total TOP1MT.
    Homologie
    Pig,Zebrafish,Horse,Sheep,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TOP1MT, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product TOP1MT Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))
    Andere Bezeichnung
    TOP1MT (TOP1MT Produkte)
    Synonyme
    2900052H09Rik antikoerper, TOP1 antikoerper, topoisomerase (DNA) I, mitochondrial antikoerper, DNA topoisomerase 1, mitochondrial antikoerper, DNA topoisomerase I mitochondrial antikoerper, TOP1MT antikoerper, Top1mt antikoerper
    Hintergrund

    Description: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).

    Gene: TOP1MT

    Molekulargewicht
    70 kDa
    Gen-ID
    116447
    UniProt
    Q969P6
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