p63 Antikörper

Produktnummer ABIN6265681

Produktdetails anti-p63 Antikörper

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p63 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: TP63 Antibody detects endogenous levels of total TP63

Kreuzreaktivität: Human, Affe, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TP63

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Andere Bezeichnung: TP63 (TP63 Produkte)

Synonyme: AIS antikoerper, B(p51A) antikoerper, B(p51B) antikoerper, EEC3 antikoerper, KET antikoerper, LMS antikoerper, NBP antikoerper, OFC8 antikoerper, RHS antikoerper, SHFM4 antikoerper, TP53CP antikoerper, TP53L antikoerper, TP73L antikoerper, p40 antikoerper, p51 antikoerper, p53CP antikoerper, p63 antikoerper, p73H antikoerper, p73L antikoerper, TP63 antikoerper, tp63 antikoerper, DNp63 antikoerper, id:ibd3516 antikoerper, tp73l antikoerper, wu:fc89f04 antikoerper, wu:fk85h07 antikoerper, wu:fk88b02 antikoerper, Ket antikoerper, P73l antikoerper, Tp73l antikoerper, Trp63 antikoerper, TRP63 antikoerper, AI462811 antikoerper, P51/P63 antikoerper, P63 antikoerper, Tp63 antikoerper, Trp53rp1 antikoerper, Xp63 antikoerper, ket antikoerper, np63 antikoerper, tp73l-A antikoerper, trp63 antikoerper, tumor protein p63 antikoerper, transformation related protein 63 antikoerper, tumor protein p63 L homeolog antikoerper, TP63 antikoerper, tp63 antikoerper, Tp63 antikoerper, Trp63 antikoerper, tp63.L antikoerper

Hintergrund:

Description: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Gene: TP63

Molekulargewicht: 77kDa

Gen-ID: 8626

UniProt: Q9H3D4