TARBP2 Antikörper (Internal Region)

Produktnummer ABIN6265719

Produktdetails anti-TARBP2 Antikörper

Target: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TARBP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: TRBP Antibody detects endogenous levels of total TRBP.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TRBP, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu TARBP2

Target: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Andere Bezeichnung: TARBP2 (TARBP2 Produkte)

Synonyme: trbp antikoerper, trbp1 antikoerper, trbp2 antikoerper, MGC97783 antikoerper, TARBP2 antikoerper, LOQS antikoerper, TRBP antikoerper, TRBP1 antikoerper, TRBP2 antikoerper, fj51e12 antikoerper, wu:fj51e12 antikoerper, zgc:63778 antikoerper, Prbp antikoerper, TAR (HIV-1) RNA binding protein 2 antikoerper, TARBP2, RISC loading complex RNA binding subunit antikoerper, TAR (HIV-1) RNA binding protein 2 L homeolog antikoerper, TAR (HIV) RNA binding protein 2 antikoerper, tarbp2 antikoerper, TARBP2 antikoerper, tarbp2.L antikoerper, Tarbp2 antikoerper

Hintergrund:

Description: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Gene: TARBP2

Molekulargewicht: 43-46 kDa

Gen-ID: 6895

UniProt: Q15633

Pathways: Regulatorische RNA Pathways, Ribonucleoprotein Complex Subunit Organization