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TXK Antikörper (N-Term)

TXK Reaktivität: Human, Maus ELISA, WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265813
  • Target Alle TXK Antikörper anzeigen
    TXK (TXK tyrosine Kinase (TXK))
    Bindungsspezifität
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 25
    • 2
    • 1
    Human, Maus
    Wirt
    • 23
    • 3
    • 1
    Kaninchen
    Klonalität
    • 24
    • 3
    Polyklonal
    Konjugat
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TXK Antikörper ist unkonjugiert
    Applikation
    • 16
    • 14
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    TXK Antibody detects endogenous levels of total TXK.
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TXK, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product TXK Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    TXK (TXK tyrosine Kinase (TXK))
    Andere Bezeichnung
    TXK (TXK Produkte)
    Synonyme
    BTKL antikoerper, PSCTK5 antikoerper, PTK4 antikoerper, RLK antikoerper, TKL antikoerper, A130089B16Rik antikoerper, Btkl antikoerper, Rlk antikoerper, TXK tyrosine kinase antikoerper, tyrosine-protein kinase TXK antikoerper, TXK antikoerper, Txk antikoerper, LOC100544958 antikoerper
    Hintergrund

    Description: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

    Gene: TXK

    Molekulargewicht
    61 kDa
    Gen-ID
    7294
    UniProt
    P42681
    Pathways
    Regulation of Leukocyte Mediated Immunity, Hepatitis C
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