VPS11 Antikörper (Internal Region)

Produktnummer ABIN6265995

Produktdetails anti-VPS11 Antikörper

Target: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: VPS11 Antibody detects endogenous levels of total VPS11.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human VPS11, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu VPS11

Target: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Andere Bezeichnung: VPS11 (VPS11 Produkte)

Synonyme: zgc:112329 antikoerper, ATVPS11 antikoerper, F5G3.7 antikoerper, F5G3_7 antikoerper, vacuolar protein sorting 11 antikoerper, DDBDRAFT_0204454 antikoerper, DDBDRAFT_0234135 antikoerper, DDB_0204454 antikoerper, DDB_0234135 antikoerper, end1 antikoerper, pep5 antikoerper, hvps11 antikoerper, rnf108 antikoerper, 1200011A11Rik antikoerper, END1 antikoerper, PEP5 antikoerper, RNF108 antikoerper, hVPS11 antikoerper, VPS11, CORVET/HOPS core subunit antikoerper, vacuolar protein sorting 11 antikoerper, vacuolar protein sorting protein 11 antikoerper, VPS11, CORVET/HOPS core subunit S homeolog antikoerper, Vacuolar peripheral membrane protein similar to S. cerevisiae PEP5 (YMR231W); C terminus is almost identical to nonallelic CaP19.1278 antikoerper, 7-fold repeat in clathrin and VPS proteins repeat-containing protein antikoerper, vacuolar protein sorting-associated protein 11 homolog antikoerper, VPS11 CORVET/HOPS core subunit antikoerper, VPS11 antikoerper, vps11 antikoerper, MCYG_02909 antikoerper, vps11.S antikoerper, LOC100632536 antikoerper, Vps11 antikoerper

Hintergrund:

Description: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

Gene: VPS11

Molekulargewicht: 108-112 kDa

Gen-ID: 55823

UniProt: Q9H270

Pathways: SARS-CoV-2 Protein Interaktom