ZEB1 Antikörper (Internal Region)

Produktnummer ABIN6266096

Produktdetails anti-ZEB1 Antikörper

Target: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZEB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: ZEB1 Antibody detects endogenous levels of total ZEB1.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ZEB1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Referenzen für anti-ZEB1 Antikörper (ABIN6266096)

Shao, Zhang, Ma, Lu, Meng, Li, Wang, Chen, Zhang, Han, Liu, Ma: "MicroRNA-139-5p affects cisplatin sensitivity in human nasopharyngeal carcinoma cells by regulating the epithelial-to-mesenchymal transition." in: Gene, Vol. 652, pp. 48-58, (2018) (PubMed).

Li, Shen, Wang, Li, Wang, Jiang, Zhou, Feng: "EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells." in: Scientific reports, Vol. 5, pp. 11009, (2016) (PubMed).

Li, Zhang, Sun, Sun, Shi, Liu, Liu: "MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells." in: International journal of oncology, Vol. 47, Issue 4, pp. 1379-92, (2016) (PubMed).

Details zu ZEB1

Target: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Andere Bezeichnung: ZEB1 (ZEB1 Produkte)

Synonyme: ZFH/[d]EF1 antikoerper, kheper antikoerper, zeb1 antikoerper, zfhx1 antikoerper, bzp antikoerper, zeb antikoerper, tcf8 antikoerper, areb6 antikoerper, nil2a antikoerper, zfhep antikoerper, nil-2a antikoerper, zfhx1a antikoerper, nil-2-a antikoerper, MGC97552 antikoerper, TCF8 antikoerper, AREB6 antikoerper, BZP antikoerper, DELTAEF1 antikoerper, FECD6 antikoerper, NIL2A antikoerper, PPCD3 antikoerper, ZFHEP antikoerper, ZFHX1A antikoerper, 3110032K11Rik antikoerper, MEB1 antikoerper, Nil2 antikoerper, TCF-8 antikoerper, Tcf18 antikoerper, Tcf8 antikoerper, Tw antikoerper, ZEB antikoerper, Zfhep antikoerper, Zfhx1a antikoerper, Zfx1a antikoerper, Zfx1ha antikoerper, [delta]EF1 antikoerper, deltaEF1 antikoerper, deltaef1 antikoerper, fecd6 antikoerper, zinc finger E-box binding homeobox 1b antikoerper, zinc finger E-box binding homeobox 1 antikoerper, zinc finger E-box binding homeobox 1 S homeolog antikoerper, zeb1b antikoerper, zeb1 antikoerper, ZEB1 antikoerper, Zeb1 antikoerper, zeb1.S antikoerper

Hintergrund:

Description: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Gene: ZEB1

Molekulargewicht: 124kDa

Gen-ID: 6935

UniProt: P37275

Pathways: Regulation of Muscle Cell Differentiation