ZNF598 Antikörper (N-Term)

Produktnummer ABIN6266100

Produktdetails anti-ZNF598 Antikörper

Target: ZNF598 (Zinc Finger Protein 598 (ZNF598))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNF598 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: ZFP598 Antibody detects endogenous levels of total ZFP598.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ZFP598, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ZNF598

Target: ZNF598 (Zinc Finger Protein 598 (ZNF598))

Andere Bezeichnung: ZNF598 (ZNF598 Produkte)

Synonyme: ZNF598 antikoerper, BC023040 antikoerper, Ntrap antikoerper, Znf598 antikoerper, Zfp598 antikoerper, wu:fc88f12 antikoerper, zinc finger protein 598 antikoerper, ZNF598 antikoerper, znf598 antikoerper, Zfp598 antikoerper

Hintergrund:

Description: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931).

Gene: ZNF598

Molekulargewicht: 98 kDa

Gen-ID: 90850

UniProt: Q86UK7