PIWIL2 Antikörper (C-Term)
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- Target Alle PIWIL2 Antikörper anzeigen
- PIWIL2 (Piwi-Like 2 (PIWIL2))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PIWIL2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- PIWIL2 Antibody detects endogenous levels of total PIWIL2.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human PIWIL2, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product PIWIL2 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:1000, IHC 1:20-1:50, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- PIWIL2 (Piwi-Like 2 (PIWIL2))
- Andere Bezeichnung
- PIWIL2 (PIWIL2 Produkte)
- Synonyme
- si:dkey-88f5.1 antikoerper, zili antikoerper, Piwil1l antikoerper, mili antikoerper, CT80 antikoerper, HILI antikoerper, PIWIL1L antikoerper, piwil2 antikoerper, piwi like RNA-mediated gene silencing 2 antikoerper, piwi-like RNA-mediated gene silencing 2 antikoerper, piwil2 antikoerper, Piwil2 antikoerper, PIWIL2 antikoerper
- Hintergrund
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Description: Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660).
Gene: PIWIL2
- Molekulargewicht
- 110kDa
- Gen-ID
- 55124
- UniProt
- Q8TC59
- Pathways
- Stem Cell Maintenance
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