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CD44 Antikörper (Internal Region)

Name: CD44 Antikörper (Internal Region)
SKU: ABIN6266329
Price: 864 EUR
Availability: InStock

CD44 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

Western blot analysis of MCF7 lysate using CD44 antibody. (CD44 Antikörper (Internal Region))

ABIN6276659 at 1/100 staining Human liver cancer tissue by IHC-P. (CD44 Antikörper (Internal Region))

IHC

IF/ICC

3 Abbildungen

(1 reference)

Produktnummer ABIN6266329

Datenblatt (PDF)

Target Alle CD44 Antikörper anzeigen

CD44
Bindungsspezifität
16

16

16

10

8

5

4

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region
Reaktivität
297

153

74

32

25

22

14

13

10

9

8

7

7

5

5

4

2

2

1

1

1

1

1
Human, Maus, Ratte
Wirt
179

117

91

1

1
Kaninchen
Passende Sekundärantikörper
Klonalität
283

103

3
Polyklonal
Konjugat
178

47

32

23

18

7

6

5

5

5

5

4

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Dieser CD44 Antikörper ist unkonjugiert
Applikation
292

152

92

80

71

71

59

45

40

30

27

15

9

7

7

6

5

5

4

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität

CD44 Antibody detects endogenous levels of total CD44.

Homologie

Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen

A synthesized peptide derived from human CD44, corresponding to a region within the internal amino acids.

Isotyp

IgG

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CD44 Reaktivität: Human WB, IHC (p) Wirt: Maus Polyclonal unconjugated

Applikationshinweise

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit

12 months
Xie, Huang, Tang, Ye, Yang, Guo, Tian, Xie, Peng, Xie: "Diallyl Disulfide Inhibits Breast Cancer Stem Cell Progression and Glucose Metabolism by Targeting CD44/PKM2/AMPK Signaling." in: Current cancer drug targets, Vol. 18, Issue 6, pp. 592-599, (2018) (PubMed).
Target

CD44

Andere Bezeichnung

CD44 (CD44 Produkte)

Hintergrund

Description: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9, the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).
Gene: CD44

Molekulargewicht

82kDa

Gen-ID

960

UniProt

P16070

Pathways

Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling