PRKAA1/PRKAA2 Antikörper (Thr172, Thr183)
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- Target Alle PRKAA1/PRKAA2 Produkte
- PRKAA1/PRKAA2 (AMPK1/AMPK2)
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Bindungsspezifität
- AA 110-190, Thr172, Thr183
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Reaktivität
- Human, Maus, Ratte, Affe
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PRKAA1/PRKAA2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Verwendungszweck
- AMPKα1/2 is a protein encoded by the PRKAA1 gene which is approximately 64 kDa. AMPKα1/2 is localised to the cytoplasm and nucleus. It is involved in RET signalling, mTOR signalling, AMP-activated protein kinase signalling, the regulation of TP53 activity and longevity regulating pathway. It is a catalytic subunit of AMP-activated protein kinase, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, it activates energy-producing pathways and inhibits energy-consuming processes such as protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPKα1/2 is expressed in nervous system, liver, blood, intestine and kidney. Mutations in the PRKAA1 gene may result in obesity. STJ91581 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AMPKα1/2 protein.
- Spezifität
- AMPKα1/2 Polyclonal Antibody detects endogenous levels of AMPKα1/2 protein.
- Produktmerkmale
- Rabbit polyclonal to AMPKα1/2.
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from human AMPKalpha1/2 around the non-phosphorylation site of T183/172.
- Isotyp
- IgG
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- Applikationshinweise
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WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- PRKAA1/PRKAA2 (AMPK1/AMPK2)
- Andere Bezeichnung
- AMPKalpha1/2 (PRKAA1/PRKAA2 Produkte)
- Synonyme
- AMPK antikoerper, AMPK2 antikoerper, AMPKa2 antikoerper, PRKAA antikoerper, Ampk antikoerper, Ampka2 antikoerper, 2310008I11Rik antikoerper, A830082D05 antikoerper, AMPKalpha2 antikoerper, protein kinase AMP-activated catalytic subunit alpha 2 antikoerper, protein kinase, AMP-activated, alpha 2 catalytic subunit antikoerper, PRKAA2 antikoerper, Prkaa2 antikoerper
- Molekulargewicht
- 63 kDa
- Gen-ID
- 5562
- UniProt
- Q13131
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