APH1A Antikörper
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- Target Alle APH1A Antikörper anzeigen
- APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser APH1A Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- Affinity purification
- Immunogen
- A synthetic peptide of human APH1A
- Isotyp
- IgG
- Top Product
- Discover our top product APH1A Primärantikörper
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- Applikationshinweise
- WB 1:500 - 1:2000
- Kommentare
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Widely expressed, Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain, Isoform 1 and isoform 2 are nearly expressed at the same level
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20C. Avoid freeze / thaw cycles.
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- Target
- APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
- Andere Bezeichnung
- APH1A (APH1A Produkte)
- Synonyme
- 6530402N02Rik antikoerper, APH-1 antikoerper, APH-1A antikoerper, CGI-78 antikoerper, RGD1311546 antikoerper, APH-1a antikoerper, aph-1 homolog A, gamma-secretase subunit antikoerper, aph-1 homolog A, gamma secretase subunit L homeolog antikoerper, aph-1 homolog A, gamma secretase subunit antikoerper, anterior pharynx defective 1 homolog A (C. elegans) antikoerper, aph1 homolog A, gamma secretase subunit antikoerper, acylamino-acid-releasing enzyme-like antikoerper, APH1A antikoerper, aph1a.L antikoerper, Aph1a antikoerper, LOC100219182 antikoerper
- Hintergrund
- This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
- Molekulargewicht
- 28.996 kDa
- Gen-ID
- 51107
- UniProt
- Q96BI3
- Pathways
- Notch Signalweg, Neurotrophin Signalübertragung
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