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ULBP1 Antikörper (N-Term)

ULBP1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN634554
  • Target Alle ULBP1 Antikörper anzeigen
    ULBP1 (UL16 Binding Protein 1 (ULBP1))
    Bindungsspezifität
    • 7
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 19
    • 1
    Human
    Wirt
    • 17
    • 2
    Kaninchen
    Klonalität
    • 17
    • 2
    Polyklonal
    Konjugat
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ULBP1 Antikörper ist unkonjugiert
    Applikation
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    ULBP1 antibody was raised against the N terminal of ULBP1
    Aufreinigung
    Affinity purified
    Immunogen
    ULBP1 antibody was raised using the N terminal of ULBP1 corresponding to a region with amino acids MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSRPEPQWC
    Top Product
    Discover our top product ULBP1 Primärantikörper
  • Applikationshinweise
    WB: 1 µg/mL
    Optimal conditions should be determined by the investigator.
    Kommentare

    ULBP1 Blocking Peptide, catalog no. 33R-5583, is also available for use as a blocking control in assays to test for specificity of this ULBP1 antibody

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of ULBP1 antibody in PBS
    Konzentration
    Lot specific
    Buffer
    PBS
    Handhabung
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Target
    ULBP1 (UL16 Binding Protein 1 (ULBP1))
    Andere Bezeichnung
    ULBP1 (ULBP1 Produkte)
    Synonyme
    RAET1I antikoerper, A430108B07Rik antikoerper, MULT1 antikoerper, ULBP1 antikoerper, UL16 binding protein 1 antikoerper, UL16 binding protein 21 antikoerper, NKG2D ligand 1 antikoerper, ULBP1 antikoerper, ULBP21 antikoerper, Ulbp1 antikoerper, LOC100683099 antikoerper
    Hintergrund
    ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
    Molekulargewicht
    28 kDa (MW of target protein)
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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