MIA
Reaktivität: Human
Wirt: Kaninchen
Polyclonal
FITC
Applikationshinweise
Optimal conditions should be determined byt he investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Konzentration
Lot specific
Buffer
Lyophilized from PBS, pH 7.2.
Handhabung
Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.
CD-RAP antikoerper, Mia1 antikoerper, Cdrap antikoerper, zgc:194157 antikoerper, mia antikoerper, CDRAP antikoerper, Fdp antikoerper, MIA antikoerper, MIAL antikoerper, melanoma inhibitory activity antikoerper, otoraplin antikoerper, cilia and flagella associated protein 100 antikoerper, MIA antikoerper, Mia antikoerper, mia antikoerper, Otor antikoerper, CFAP100 antikoerper
Hintergrund
MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family, MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis.