This product reacts with the C-terminus cytoplasmic domain of ryanodine receptor. Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscle cells. OBT1818 reacts with ryanodine receptor (MW approx. 500kDa) isolated from a variety of cell types (e.g. lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscle, cardiac muscle and brain tissues).
Kreuzreaktivität
Rind (Kuh), Hund, Maus, Schwein, Ratte (Rattus)
Aufreinigung
Purified
Immunogen
Short synthetic polypeptide corresponding to the C-terminal domain of the ryanodine receptor.