PTRH2 Antikörper (AA 80-110)

Produktnummer ABIN650622

Produktdetails anti-PTRH2 Antikörper

Target: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Bindungsspezifität: AA 80-110

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTRH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Bit1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-110 amino acids from the Central region of human Bit1.

Klon: RB06095

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu PTRH2

Target: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Andere Bezeichnung: Bit1 (PTRH2 Produkte)

Synonyme: BIT1 antikoerper, PTH2 antikoerper, A230072I16Rik antikoerper, Bit1 antikoerper, CGI-147 antikoerper, wu:fj09f02 antikoerper, zgc:109954 antikoerper, RGD1306819 antikoerper, peptidyl-tRNA hydrolase 2 antikoerper, ptrh2 antikoerper, CC1G_10259 antikoerper, ANI_1_1036184 antikoerper, AOR_1_2082154 antikoerper, PTRH2 antikoerper, Ptrh2 antikoerper

Hintergrund: Adhesion to extracellular matrix regulates cell survival via integrin engagement and cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. A role for Bit1 (Bcl-2 inhibitor of transcription 1) has been identified in this process. Bit1 is a mitochondrial protein released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. Bit1-AES complexes may switch off a survival-promoting gene transcription program controlled by TLE. Apoptosis of Bit1/AES transfected cells is inhibited when cells are permitted to attach to fibronectin through the alpha-beta integrin, suggesting that the contribution of the Bit1-AES pathway to anoikis is regulated by integrins.

Molekulargewicht: 19194

Gen-ID: 51651

NCBI Accession: NP_057161

UniProt: Q9Y3E5