RUVBL1 Antikörper (AA 247-280)

Produktnummer ABIN650670

Produktdetails anti-RUVBL1 Antikörper

Target: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Bindungsspezifität: AA 247-280

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RUVBL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Zf, M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RUVBL1 (TIP49) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-280 amino acids from the Central region of human RUVBL1 (TIP49).

Klon: RB8415

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu RUVBL1

Target: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Andere Bezeichnung: RUVBL1 (TIP49) (RUVBL1 Produkte)

Synonyme: rvb1 antikoerper, ecp54 antikoerper, tip49 antikoerper, nmp238 antikoerper, pontin antikoerper, tip49a antikoerper, xpontin antikoerper, pontin52 antikoerper, TIP49 antikoerper, wu:fd18e04 antikoerper, zpontin antikoerper, ECP54 antikoerper, INO80H antikoerper, NMP238 antikoerper, PONTIN antikoerper, Pontin52 antikoerper, RVB1 antikoerper, TIH1 antikoerper, TIP49A antikoerper, Tip49a antikoerper, 2510009G06Rik antikoerper, RuvB like AAA ATPase 1 antikoerper, RuvB-like 1 (E. coli) antikoerper, RuvB-like 1 antikoerper, RuvB like AAA ATPase 1 S homeolog antikoerper, RuvB-like AAA ATPase 1 antikoerper, RuvB-like protein 1 antikoerper, RUVBL1 antikoerper, ruvbl1 antikoerper, PVX_123295 antikoerper, Bm1_15605 antikoerper, ruvb1 antikoerper, ruvbl1.S antikoerper, Ruvbl1 antikoerper

Hintergrund: RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1 -CTNNB1 complex. High levels of autoantibodies against RUVBL1 are detected in sera of patients with autoimmune diseases such as polymyositis/dermatomyosistis and autoimmune hepatitis.

Molekulargewicht: 50228

Gen-ID: 8607

NCBI Accession: NP_003698

UniProt: Q9Y265

Pathways: Telomere Maintenance