This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This GNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GNB1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Liu, Qin, Yu, Soares, Yang, Weng, Li, Gao, Lu, Hu, Liu, Jiang, Liu, Shu, Tang, Liu: "Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish." in: The Journal of biological chemistry, Vol. 292, Issue 15, pp. 6225-6239, (2017) (PubMed).
Liu, Chen, Yu, Raghupathy, Liu, Qin, Li, Huang, Liao, Wang, Zou, Shu, Tang, Liu: "Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish." in: Human molecular genetics, Vol. 24, Issue 16, pp. 4648-59, (2015) (PubMed).
GNB1 integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This protein uses alternative polyadenylation signals.