ADRA2B Antikörper (AA 343-369)

Produktnummer ABIN652506

Produktdetails anti-ADRA2B Antikörper

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Bindungsspezifität: AA 343-369

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRA2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ADRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-369 amino acids from the Central region of human ADRA2B.

Klon: RB22486

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu ADRA2B

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Andere Bezeichnung: ADRA2B (ADRA2B Produkte)

Synonyme: ADRA2L1 antikoerper, ADRA2RL1 antikoerper, ADRARL1 antikoerper, ALPHA2BAR antikoerper, alpha-2BAR antikoerper, Adra-2b antikoerper, [a]2B antikoerper, alpha2-C2 antikoerper, alpha2B antikoerper, ADRA2B antikoerper, zgc:194747 antikoerper, Adra2b antikoerper, adrenoceptor alpha 2B antikoerper, adrenergic receptor, alpha 2b antikoerper, adrenergic, alpha-2B-, receptor antikoerper, adrenoceptor alpha 2C antikoerper, ADRA2B antikoerper, Adra2b antikoerper, ADRA2C antikoerper, adra2b antikoerper

Hintergrund: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.

Molekulargewicht: 49954

Gen-ID: 151

NCBI Accession: NP_000673

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process