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ADRA2B Antikörper (AA 343-369)

ADRA2B Reaktivität: Human WB, IF, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB22486 unconjugated
Produktnummer ABIN652506
  • Target Alle ADRA2B Antikörper anzeigen
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Bindungsspezifität
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 343-369
    Reaktivität
    • 22
    • 5
    • 4
    Human
    Wirt
    • 22
    • 2
    • 1
    Kaninchen
    Klonalität
    • 23
    • 2
    Polyklonal
    Konjugat
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ADRA2B Antikörper ist unkonjugiert
    Applikation
    • 16
    • 9
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ADRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-369 amino acids from the Central region of human ADRA2B.
    Klon
    RB22486
    Isotyp
    IgG
  • Applikationshinweise
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Andere Bezeichnung
    ADRA2B (ADRA2B Produkte)
    Synonyme
    ADRA2L1 antikoerper, ADRA2RL1 antikoerper, ADRARL1 antikoerper, ALPHA2BAR antikoerper, alpha-2BAR antikoerper, Adra-2b antikoerper, [a]2B antikoerper, alpha2-C2 antikoerper, alpha2B antikoerper, ADRA2B antikoerper, zgc:194747 antikoerper, Adra2b antikoerper, adrenoceptor alpha 2B antikoerper, adrenergic receptor, alpha 2b antikoerper, adrenergic, alpha-2B-, receptor antikoerper, adrenoceptor alpha 2C antikoerper, ADRA2B antikoerper, Adra2b antikoerper, ADRA2C antikoerper, adra2b antikoerper
    Hintergrund
    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
    Molekulargewicht
    49954
    Gen-ID
    151
    NCBI Accession
    NP_000673
    UniProt
    P18089
    Pathways
    EGFR Signaling Pathway, cAMP Metabolic Process
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