This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This NR1I2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-127 amino acids from the Central region of human NR1I2.
BXR antikoerper, ONR1 antikoerper, PAR antikoerper, PAR1 antikoerper, PAR2 antikoerper, PARq antikoerper, PRR antikoerper, PXR antikoerper, SAR antikoerper, SXR antikoerper, PXR.1 antikoerper, PXR.2 antikoerper, PXR1 antikoerper, mPXR antikoerper, bxr antikoerper, nr1i2 antikoerper, onr1 antikoerper, xonr1 antikoerper, nuclear receptor subfamily 1 group I member 2 antikoerper, nuclear receptor subfamily 1, group I, member 2 antikoerper, nuclear receptor subfamily 1 group I member 2 S homeolog antikoerper, NR1I2 antikoerper, Nr1i2 antikoerper, nr1i2.S antikoerper, nr1i2 antikoerper
Hintergrund
NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. This protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin.