HMGA1 Antikörper (C-Term)

Produktnummer ABIN653050

Produktdetails anti-HMGA1 Antikörper

Target: HMGA1 (High Mobility Group AT-Hook 1 (HMGA1))

Bindungsspezifität: AA 64-93, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMGA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Homologie: Ha, M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HMGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-93 amino acids from the C-terminal region of human HMGA1.

Klon: RB17645

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. WB: 1:1000. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-HMGA1 Antikörper (ABIN653050)

Liu, Zhang, Li, Ding, Tu, Zhou, Qi, Chen, Sun: "Let-7a inhibits growth and migration of breast cancer cells by targeting HMGA1." in: International journal of oncology, Vol. 46, Issue 6, pp. 2526-34, (2015) (PubMed).

Details zu HMGA1

Target: HMGA1 (High Mobility Group AT-Hook 1 (HMGA1))

Andere Bezeichnung: HMGA1 (HMGA1 Produkte)

Hintergrund: HMGA1 encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus.

Molekulargewicht: 11676

Gen-ID: 3159

NCBI Accession: NP_002122, NP_665906, NP_665908, NP_665909, NP_665910, NP_665912

UniProt: P17096

Pathways: Nuclear Hormone Receptor Binding, Autophagie