This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This GINS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GINS1.
GINS1
Reaktivität: Human
Wirt: Kaninchen
Polyclonal
FITC
Applikationshinweise
WB: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Kang, Farina, Bermudez, Tappin, Du, Galal, Hurwitz: "Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 49, pp. 19760-5, (2013) (PubMed).
Kang, Galal, Farina, Tappin, Hurwitz: "Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 16, pp. 6042-7, (2012) (PubMed).
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4, MIM 610611), Psf1, Psf2 (GINS2, MIM 610609), and Psf3 (GINS3, MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).