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CHMP4B Antikörper (N-Term)

CHMP4B Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB24088 unconjugated
Produktnummer ABIN653481
  • Target Alle CHMP4B Antikörper anzeigen
    CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
    Bindungsspezifität
    • 15
    • 7
    • 6
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    AA 51-79, N-Term
    Reaktivität
    • 44
    • 22
    • 14
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 43
    • 1
    Kaninchen
    Klonalität
    • 43
    • 1
    Polyklonal
    Konjugat
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CHMP4B Antikörper ist unkonjugiert
    Applikation
    • 19
    • 19
    • 18
    • 13
    • 13
    • 11
    • 4
    • 3
    • 3
    • 3
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    C, Zf, M, X
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CHMP4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human CHMP4B.
    Klon
    RB24088
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CHMP4B Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Hu, Jiang, Chen, Wei, Zhang, Zhao, Ni, Lu, Wan: "High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular carcinoma." in: Tumour biology, Vol. 36, Issue 4, pp. 2569-81, (2015) (PubMed).

  • Target
    CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
    Andere Bezeichnung
    CHMP4B (CHMP4B Produkte)
    Synonyme
    C20orf178 antikoerper, CHMP4A antikoerper, CTPP3 antikoerper, CTRCT31 antikoerper, SNF7 antikoerper, SNF7-2 antikoerper, Shax1 antikoerper, VPS32B antikoerper, Vps32-2 antikoerper, dJ553F4.4 antikoerper, 2010012F05Rik antikoerper, C76846 antikoerper, Snf7-2 antikoerper, RGD1309846 antikoerper, RGD1565889 antikoerper, CHMP4b antikoerper, chmp4b antikoerper, chmp4b.S antikoerper, CHMP4c antikoerper, c20orf178 antikoerper, wu:fc96b02 antikoerper, zgc:55566 antikoerper, charged multivesicular body protein 4B antikoerper, charged multivesicular body protein 4Ba antikoerper, charged multivesicular body protein 4B L homeolog antikoerper, charged multivesicular body protein 4Bb antikoerper, CHMP4B antikoerper, Chmp4b antikoerper, chmp4ba antikoerper, chmp4b.L antikoerper, chmp4bb antikoerper
    Hintergrund
    CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.
    Molekulargewicht
    24950
    Gen-ID
    128866
    NCBI Accession
    NP_789782
    UniProt
    Q9H444
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