Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This COX6A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the Central region of human COX6A2.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Boczonadi, Giunta, Lane, Tulinius, Schara, Horvath: "Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease." in: The international journal of biochemistry & cell biology, (2015) (PubMed).
Target
COX6A2
(Cytochrome C Oxidase Subunit VIa Polypeptide 2 (COX6A2))
COX6AH antikoerper, COXVIAH antikoerper, CoxVIaH antikoerper, VIaH antikoerper, cytochrome c oxidase subunit 6A2 antikoerper, cytochrome c oxidase subunit VIa polypeptide 2 antikoerper, COX6A2 antikoerper, Cox6a2 antikoerper
Hintergrund
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66 % amino acid sequence identity.