MARCO Antikörper (AA 13-40)

Produktnummer ABIN653847

Produktdetails anti-MARCO Antikörper

Target: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Bindungsspezifität: AA 13-40

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARCO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MARCO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids of human MARCO.

Klon: RB24662

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-MARCO Antikörper (ABIN653847)

Ohta, Moriyama, Maehara, Gion, Furukawa, Tanaka, Hayashida, Yamauchi, Ishiguro, Mikami, Tsuboi, Iizuka-Koga, Kawano, Sato, Kiyoshima, Sumida, Nakamura: "DNA Microarray Analysis of Submandibular Glands in IgG4-Related Disease Indicates a Role for MARCO and Other Innate Immune-Related Proteins." in: Medicine, Vol. 95, Issue 7, pp. e2853, (2016) (PubMed).

Chao, Makale, Karmali, Sharikov, Tsigelny, Merkulov, Kesari, Wrasidlo, Ruoslahti, Simberg: "Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor charged domains." in: Bioconjugate chemistry, Vol. 23, Issue 5, pp. 1003-9, (2014) (PubMed).

Details zu MARCO

Target: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Andere Bezeichnung: MARCO (MARCO Produkte)

Hintergrund: MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.

Molekulargewicht: 52658

Gen-ID: 8685

NCBI Accession: NP_006761

UniProt: Q9UEW3

Pathways: Activation of Innate immune Response