This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This RGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-291 amino acids from the Central region of human RGR.
RP44 antikoerper, MGC84794 antikoerper, RGR antikoerper, rgr antikoerper, zgc:110660 antikoerper, rgr2 antikoerper, wu:fb64c10 antikoerper, zgc:109930 antikoerper, retinal G protein coupled receptor antikoerper, retinal G protein coupled receptor L homeolog antikoerper, retinal G protein coupled receptor a antikoerper, retinal G protein coupled receptor b antikoerper, RGR antikoerper, Rgr antikoerper, rgr.L antikoerper, rgr antikoerper, rgra antikoerper, rgrb antikoerper
Hintergrund
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively).