RAD17 Antikörper (AA 218-246)

Produktnummer ABIN655646

Produktdetails anti-RAD17 Antikörper

Target: RAD17

Bindungsspezifität: AA 218-246

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RAD17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human RAD17.

Klon: RB20035

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu RAD17

Target: RAD17

Andere Bezeichnung: RAD17 (RAD17 Produkte)

Synonyme: zgc:91969 antikoerper, RAD17 antikoerper, K2A18.21 antikoerper, K2A18_21 antikoerper, RADIATION SENSITIVE 17 antikoerper, CCYC antikoerper, HRAD17 antikoerper, R24L antikoerper, RAD17SP antikoerper, RAD24 antikoerper, 9430035O09Rik antikoerper, MmRad24 antikoerper, RAD17 checkpoint clamp loader component antikoerper, Rad17p antikoerper, RADIATION SENSITIVE 17 antikoerper, RAD17 antikoerper, rad17 antikoerper, ATRAD17 antikoerper, Rad17 antikoerper

Hintergrund: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

Molekulargewicht: 77055

Gen-ID: 5884

NCBI Accession: NP_001265551, NP_002864, NP_579916, NP_579917, NP_579918, NP_579919, NP_579920, NP_579921, NP_579922

UniProt: O75943