PPARD Antikörper (C-Term)

Produktnummer ABIN655880

Produktdetails anti-PPARD Antikörper

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Bindungsspezifität: AA 367-394, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPARD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PPARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-394 amino acids from the C-terminal region of human PPARD.

Klon: RB31677

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu PPARD

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Andere Bezeichnung: PPARD (PPARD Produkte)

Synonyme: FAAR antikoerper, NR1C2 antikoerper, NUC1 antikoerper, NUCI antikoerper, NUCII antikoerper, PPARB antikoerper, NUC-1 antikoerper, Nr1c2 antikoerper, PPAR-beta antikoerper, PPAR-delta antikoerper, PPAR[b] antikoerper, PPARdelta antikoerper, Pparb antikoerper, Pparb/d antikoerper, PPARBETA antikoerper, ppard antikoerper, pparb antikoerper, PPARD antikoerper, PPAR-D/B antikoerper, peroxisome proliferator activated receptor delta antikoerper, peroxisome proliferator activator receptor delta antikoerper, peroxisome proliferator activated receptor delta S homeolog antikoerper, peroxisome proliferator-activated receptor delta antikoerper, PPARD antikoerper, Ppard antikoerper, ppard.S antikoerper, ppard antikoerper

Hintergrund: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

Molekulargewicht: 49903

Gen-ID: 5467

NCBI Accession: NP_001165289, NP_001165290, NP_001165291, NP_006229, NP_803184

UniProt: Q03181

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation