Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PIGA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 455-484 amino acids from the C-terminal region of human PIGA.
GPI3 antikoerper, MCAHS2 antikoerper, PIG-A antikoerper, AI194334 antikoerper, Pig-a antikoerper, im:6911675 antikoerper, zgc:56589 antikoerper, phosphatidylinositol glycan anchor biosynthesis class A antikoerper, phosphatidylinositol glycan anchor biosynthesis, class A antikoerper, PIGA antikoerper, Piga antikoerper, piga antikoerper
Hintergrund
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.