PDP Antikörper (AA 308-336)

Produktnummer ABIN656386

Produktdetails anti-PDP Antikörper

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Bindungsspezifität: AA 308-336

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1.

Klon: RB31327

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: PDP1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Referenzen für anti-PDP Antikörper (ABIN656386)

Shan, Kang, Elf, Xie, Gu, Aguiar, Lonning, Hitosugi, Chung, Arellano, Khoury, Shin, Khuri, Boggon, Fan: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." in: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).

Details zu PDP

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Andere Bezeichnung: PDP1 (PDP Produkte)

Synonyme: 153332_at antikoerper, CG12151 antikoerper, Dmel\\CG12151 antikoerper, PDP antikoerper, pdp antikoerper, PDH antikoerper, PDPC antikoerper, PPM2C antikoerper, Gm1024 antikoerper, Ppm2c antikoerper, im:7157162 antikoerper, zgc:174908 antikoerper, pdp1 antikoerper, ppm2c antikoerper, Pyruvate dehydrogenase phosphatase antikoerper, pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial antikoerper, pyruvate dehyrogenase phosphatase catalytic subunit 1 antikoerper, pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog antikoerper, Pdp antikoerper, LOC413080 antikoerper, PDP1 antikoerper, Pdp1 antikoerper, pdp1 antikoerper, pdp1.L antikoerper

Hintergrund: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Molekulargewicht: 61054

Gen-ID: 54704

NCBI Accession: NP_001155251, NP_001155252, NP_001155253, NP_060914

UniProt: Q9P0J1