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PDP Antikörper (AA 308-336)

PDP Reaktivität: Human, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal RB31327 unconjugated
Produktnummer ABIN656386
  • Target Alle PDP Antikörper anzeigen
    PDP (Pyruvate Dehydrogenase Phosphatase (PDP))
    Bindungsspezifität
    • 15
    • 7
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 308-336
    Reaktivität
    • 52
    • 13
    • 10
    • 1
    Human, Ratte
    Wirt
    • 50
    • 1
    • 1
    Kaninchen
    Klonalität
    • 51
    • 1
    Polyklonal
    Konjugat
    • 17
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PDP Antikörper ist unkonjugiert
    Applikation
    • 38
    • 21
    • 18
    • 13
    • 13
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1.
    Klon
    RB31327
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    PDP1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    Haltbarkeit
    6 months
  • Shan, Kang, Elf, Xie, Gu, Aguiar, Lonning, Hitosugi, Chung, Arellano, Khoury, Shin, Khuri, Boggon, Fan: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." in: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).

  • Target
    PDP (Pyruvate Dehydrogenase Phosphatase (PDP))
    Andere Bezeichnung
    PDP1 (PDP Produkte)
    Synonyme
    153332_at antikoerper, CG12151 antikoerper, Dmel\\CG12151 antikoerper, PDP antikoerper, pdp antikoerper, PDH antikoerper, PDPC antikoerper, PPM2C antikoerper, Gm1024 antikoerper, Ppm2c antikoerper, im:7157162 antikoerper, zgc:174908 antikoerper, pdp1 antikoerper, ppm2c antikoerper, Pyruvate dehydrogenase phosphatase antikoerper, pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial antikoerper, pyruvate dehyrogenase phosphatase catalytic subunit 1 antikoerper, pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog antikoerper, Pdp antikoerper, LOC413080 antikoerper, PDP1 antikoerper, Pdp1 antikoerper, pdp1 antikoerper, pdp1.L antikoerper
    Hintergrund
    Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
    Molekulargewicht
    61054
    Gen-ID
    54704
    NCBI Accession
    NP_001155251, NP_001155252, NP_001155253, NP_060914
    UniProt
    Q9P0J1
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