PML Antikörper
-
- Target Alle PML Antikörper anzeigen
- PML (Promyelocytic Leukemia (PML))
-
Reaktivität
- Human, Maus
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser PML Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant protein of human PML
- Isotyp
- IgG
- Top Product
- Discover our top product PML Primärantikörper
-
-
- Applikationshinweise
- WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- PML (Promyelocytic Leukemia (PML))
- Andere Bezeichnung
- PML (PML Produkte)
- Synonyme
- MYL antikoerper, PP8675 antikoerper, RNF71 antikoerper, TRIM19 antikoerper, 1200009E24Rik antikoerper, AI661194 antikoerper, Trim19 antikoerper, RGD1562602 antikoerper, PML antikoerper, promyelocytic leukemia antikoerper, PML antikoerper, Pml antikoerper
- Hintergrund
-
Synonyms: Acure promyelocytic leukemia,inducer of,MYL,Pml,PML,PP8675,Probable transcription factor PML,Promyelocytic leukemia,Promyelocytic leukemia inducer of,Promyelocytic leukemia protein,Protein PML,RING finger protein 71,RNF 71,RNF71,TRIM 19,Tripartite motif protein TRIM19,Tripartite motif-containing protein 19
Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
- Molekulargewicht
-
Observed_MW: 98kDa
Calculated_MW: 47-48kDa/62-97kDa
- Gen-ID
- 5371
- UniProt
- P29590
- Pathways
- p53 Signalweg, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
-