This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This STARD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human STARD5.
STARD5 antikoerper, MGC131265 antikoerper, DKFZp469N2125 antikoerper, 2310058G22Rik antikoerper, AI607880 antikoerper, D7Ertd152e antikoerper, RGD1561783 antikoerper, StAR related lipid transfer domain containing 5 antikoerper, StAR related lipid transfer domain containing 5 S homeolog antikoerper, StAR-related lipid transfer (START) domain containing 5 antikoerper, StAR-related lipid transfer domain containing 5 antikoerper, STARD5 antikoerper, stard5.S antikoerper, Stard5 antikoerper
Hintergrund
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1, MIM 184756) and by liver X receptors (e.g., LXRA, MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR, MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]).