IL12RB1 Antikörper
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- Target Alle IL12RB1 Antikörper anzeigen
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser IL12RB1 Antikörper ist unkonjugiert
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Applikation
- Immunofluorescence (IF)
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human IL12RB1 (NP_714912.1).
- Isotyp
- IgG
- Top Product
- Discover our top product IL12RB1 Primärantikörper
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- Applikationshinweise
- IF 1:10-1:100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
- Andere Bezeichnung
- IL12RB1 (IL12RB1 Produkte)
- Synonyme
- Il12rb antikoerper, IL12RB1 antikoerper, IL-12R antikoerper, CD212 antikoerper, IL-12R-BETA1 antikoerper, IL12RB antikoerper, IL-12R[b] antikoerper, interleukin 12 receptor subunit beta 1 antikoerper, interleukin 12 receptor, beta 1 antikoerper, Il12rb1 antikoerper, IL12RB1 antikoerper
- Hintergrund
- The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
- Molekulargewicht
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Observed_MW: 73kDa
Calculated_MW: 42kDa/72kDa/73kDa
- Gen-ID
- 3594
- UniProt
- P42701
- Pathways
- JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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