DDB1 Antikörper
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- Target Alle DDB1 Antikörper anzeigen
- DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DDB1 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Aufreinigung
- Affinity purification
- Immunogen
- A synthetic peptide of human DDB1
- Isotyp
- IgG
- Top Product
- Discover our top product DDB1 Primärantikörper
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- Applikationshinweise
- IHC 1:50-1:100 IF 1:50-1:100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
- Andere Bezeichnung
- DDB1 (DDB1 Produkte)
- Synonyme
- DDBA antikoerper, UV-DDB1 antikoerper, XAP1 antikoerper, XPCE antikoerper, XPE antikoerper, XPE-BF antikoerper, DDB1 antikoerper, xpe antikoerper, ddba antikoerper, xap1 antikoerper, xpce antikoerper, xpe-bf antikoerper, uv-ddb1 antikoerper, ddb1 antikoerper, 127kDa antikoerper, AA408517 antikoerper, p127-Ddb1 antikoerper, damage specific DNA binding protein 1 antikoerper, damage-specific DNA binding protein 1, 127kDa antikoerper, DNA damage-binding protein 1 antikoerper, damage-specific DNA binding protein 1 antikoerper, DDB1 antikoerper, ddb1 antikoerper, LOC100187356 antikoerper, Ddb1 antikoerper, ddb-1 antikoerper
- Hintergrund
- The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
- Molekulargewicht
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Observed_MW: 127kDa
Calculated_MW: 50kDa/126kDa
- Gen-ID
- 100290337
- UniProt
- Q16531
- Pathways
- DNA Reparatur
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