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PCDHGA3 Antikörper (AA 284-311)

PCDHgA3 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB33029 unconjugated
Produktnummer ABIN657534
  • Target Alle PCDHGA3 (PCDHgA3) Antikörper anzeigen
    PCDHGA3 (PCDHgA3) (Protocadherin gamma A3 (PCDHgA3))
    Bindungsspezifität
    • 6
    • 6
    • 6
    • 6
    AA 284-311
    Reaktivität
    Human
    Wirt
    • 12
    Kaninchen
    Klonalität
    • 12
    Polyklonal
    Konjugat
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PCDHGA3 Antikörper ist unkonjugiert
    Applikation
    • 12
    • 12
    • 12
    • 11
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This PCDHGA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-311 amino acids from the Central region of human PCDHGA3.
    Klon
    RB33029
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    PCDHGA3 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    Haltbarkeit
    6 months
  • Zhang, Takata, Cui, Miyata-Takata, Sato, Noujima-Harada, Yoshino: "Protocadherin γ A3 is expressed in follicular lymphoma irrespective of BCL2 status and is associated with tumor cell growth." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4622-4628, (2017) (PubMed).

  • Target
    PCDHGA3 (PCDHgA3) (Protocadherin gamma A3 (PCDHgA3))
    Andere Bezeichnung
    PCDHGA3 (PCDHgA3 Produkte)
    Synonyme
    PCDH-GAMMA-A3 antikoerper, protocadherin gamma subfamily A, 3 antikoerper, PCDHGA3 antikoerper, Pcdhga3 antikoerper
    Hintergrund
    This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
    Molekulargewicht
    100971
    Gen-ID
    56112
    NCBI Accession
    NP_061739, NP_114400
    UniProt
    Q9Y5H0
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