ITCH Antikörper (AA 509-536)

Produktnummer ABIN657549

Produktdetails anti-ITCH Antikörper

Target: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Bindungsspezifität: AA 509-536

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITCH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-536 amino acids from the Central region of human ITCH.

Klon: RB33154

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: ITCH Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Details zu ITCH

Target: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Andere Bezeichnung: ITCH (ITCH Produkte)

Synonyme: AIF4 antikoerper, AIP4 antikoerper, NAPP1 antikoerper, dJ468O1.1 antikoerper, 6720481N21Rik antikoerper, 8030492O04Rik antikoerper, A130065M08 antikoerper, C230047C07Rik antikoerper, itchy E3 ubiquitin protein ligase antikoerper, itchy, E3 ubiquitin protein ligase antikoerper, ITCH antikoerper, Itch antikoerper

Hintergrund: Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

Molekulargewicht: 102803

Gen-ID: 83737

NCBI Accession: NP_001244066, NP_001244067, NP_113671

UniProt: Q96J02

Pathways: Activation of Innate immune Response, CXCR4-mediated Signaling Events