MMP2 Antikörper (AA 303-331)
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- Target Alle MMP2 Antikörper anzeigen
- MMP2 (Matrix Metalloproteinase 2 (MMP2))
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Bindungsspezifität
- AA 303-331
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MMP2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Homologie
- C, M, Rb, Rat
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This MMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the Central region of human MMP2.
- Klon
- RB33605
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product MMP2 Primärantikörper
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- Applikationshinweise
- WB: 1:1000. WB: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- MMP2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
- Haltbarkeit
- 6 months
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Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus." in: Tumour biology, Vol. 39, Issue 5, pp. 1010428317708270, (2017) (PubMed).
: "Down-regulation of TCF21 by hypermethylation induces cell proliferation, migration and invasion in colorectal cancer." in: Biochemical and biophysical research communications, (2015) (PubMed).
: "Calreticulin promotes migration and invasion of esophageal cancer cells by upregulating neuropilin-1 expression via STAT5A." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 20, Issue 23, pp. 6153-62, (2014) (PubMed).
: "
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Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus." in: Tumour biology, Vol. 39, Issue 5, pp. 1010428317708270, (2017) (PubMed).
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- Target
- MMP2 (Matrix Metalloproteinase 2 (MMP2))
- Andere Bezeichnung
- MMP2 (MMP2 Produkte)
- Hintergrund
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
- Molekulargewicht
- 73882
- Gen-ID
- 4313
- NCBI Accession
- NP_001121363, NP_004521
- UniProt
- P08253
- Pathways
- Activation of Innate immune Response
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