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NFKBIB Antikörper (C-Term)

Dieses Anti-NFKBIB-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NFKBIB in WB und IHC (p). Geeignet für Human.
Produktnummer ABIN657702

Kurzübersicht für NFKBIB Antikörper (C-Term) (ABIN657702)

Target

Alle NFKBIB Antikörper anzeigen
NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Reaktivität

  • 105
  • 38
  • 30
  • 9
  • 8
  • 8
  • 7
  • 5
  • 4
  • 1
  • 1
  • 1
Human

Wirt

  • 98
  • 10
Kaninchen

Klonalität

  • 90
  • 18
Polyklonal

Konjugat

  • 61
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser NFKBIB Antikörper ist unkonjugiert

Applikation

  • 85
  • 40
  • 30
  • 28
  • 27
  • 19
  • 12
  • 11
  • 9
  • 5
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB33912
  • Bindungsspezifität

    • 28
    • 15
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 326-355, C-Term

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This NFKBIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-355 amino acids from the C-terminal region of human NFKBIB.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. IHC-P: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    NFKBIB Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

    Haltbarkeit

    6 months
  • Target

    NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

    Andere Bezeichnung

    NFKBIB

    Hintergrund

    NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).

    Molekulargewicht

    37771

    Gen-ID

    4793

    NCBI Accession

    NP_001230045, NP_002494

    UniProt

    Q15653

    Pathways

    NF-kappaB Signalweg, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
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