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NUMBL Antikörper (C-Term)

NUMBL Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB34676 unconjugated
Produktnummer ABIN658002
  • Target Alle NUMBL Antikörper anzeigen
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Bindungsspezifität
    • 15
    • 8
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    AA 572-600, C-Term
    Reaktivität
    • 46
    • 9
    • 9
    • 1
    Human
    Wirt
    • 44
    • 1
    • 1
    Kaninchen
    Klonalität
    • 45
    • 1
    Polyklonal
    Konjugat
    • 11
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NUMBL Antikörper ist unkonjugiert
    Applikation
    • 31
    • 22
    • 16
    • 13
    • 13
    • 4
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This NUMBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-600 amino acids from the C-terminal region of human NUMBL.
    Klon
    RB34676
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product NUMBL Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    NUMBL Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    Haltbarkeit
    6 months
  • Target
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Andere Bezeichnung
    NUMBL (NUMBL Produkte)
    Synonyme
    nbl antikoerper, numb antikoerper, cag3a antikoerper, ctg3a antikoerper, numbr antikoerper, numb-r antikoerper, tnrc23 antikoerper, numblike antikoerper, CAG3A antikoerper, CTG3a antikoerper, NBL antikoerper, NUMB-R antikoerper, NUMBLIKE antikoerper, NUMBR antikoerper, TNRC23 antikoerper, NUMB like, endocytic adaptor protein antikoerper, numb homolog-like L homeolog antikoerper, NUMB-like, endocytic adaptor protein antikoerper, numb-like antikoerper, NUMBL antikoerper, numbl.L antikoerper, Numbl antikoerper
    Hintergrund
    NUMBL plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
    Molekulargewicht
    64891
    Gen-ID
    9253
    NCBI Accession
    NP_004747
    UniProt
    Q9Y6R0
    Pathways
    Cell-Cell Junction Organization
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