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SPTA1 Antikörper (AA 356-475)

SPTA1 Reaktivität: Human IHC (p) Wirt: Kaninchen Monoclonal SPTA1-2939R unconjugated
Produktnummer ABIN6654212
  • Target Alle SPTA1 Produkte
    SPTA1 (Spectrin alpha Chain, Erythrocytic 1 (SPTA1))
    Bindungsspezifität
    AA 356-475
    Reaktivität
    Human
    Wirt
    • 2
    • 1
    Kaninchen
    Klonalität
    • 3
    Monoklonal
    Konjugat
    • 3
    Dieser SPTA1 Antikörper ist unkonjugiert
    Applikation
    • 3
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Purified
    Reinheit
    Protein A affinity chromatography
    Immunogen
    A portion of amino acids 356-475 from the human protein was used as the immunogen for the recombinant Spectrin alpha 1 antibody.
    Klon
    SPTA1-2939R
    Isotyp
    IgG kappa
  • Applikationshinweise
    Optimal dilution of the recombinant Spectrin alpha 1 antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store the recombinant Spectrin alpha 1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    SPTA1 (Spectrin alpha Chain, Erythrocytic 1 (SPTA1))
    Andere Bezeichnung
    SPTA1 / Spectrin alpha 1 (SPTA1 Produkte)
    Hintergrund
    Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. Spectrins function as membrane organizers and stabilizers, composed of non-homologous and chains, which aggregate side-to-side in an anti-parallel fashion to form dimers, tetramers and higher polymers. Spectrin Ia and spectrin Ib are present in erythrocytes, whereas spectrin IIa (also designated fodrin alpha) and spectrin IIb (also designated fodrin beta) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function.
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