Bax Inhibitor 1 Antikörper (C-Term, N-Term)

Produktnummer ABIN6655585

Produktdetails anti-Bax Inhibitor 1 Antikörper

Target: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Bindungsspezifität: C-Term, N-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Bax Inhibitor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Anti-Bi-1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Bi-1 from human, mouse and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Bi-1 from other sources has not been determined.

Immunogen:

Immunogen: Bi-1 Antibody was produced in mice prepared by repeated immunizations of a mixture of three synthetic peptides corresponding to the N-terminus, internal and C-terminus of human Bi-1 protein.

Immunogen Type: Peptide

Klon: 20F430

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry Dilution: 5-10 μg/mL

Application Note: Anti-Bi-1 antibody is suitable for use in IHC (p). Specific conditions for reactivity should be optimized by the end user.

Western Blot Dilution: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.2 % Gelatin

0.05 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: RT,4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Details zu Bax Inhibitor 1

Target: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Andere Bezeichnung: Bi-1 (TMBIM6 Produkte)

Synonyme: ARABIDOPSIS BAX INHIBITOR 1 antikoerper, ATBI-1 antikoerper, ATBI1 antikoerper, BAX INHIBITOR 1 antikoerper, BAX inhibitor 1 antikoerper, BI-1 antikoerper, K14A3.7 antikoerper, K14A3_7 antikoerper, BAXI1 antikoerper, TEGT antikoerper, 5031406P05Rik antikoerper, Bi1 antikoerper, Tegt antikoerper, Ab1-011 antikoerper, Ac1-149 antikoerper, Cc1-27 antikoerper, BAX inhibitor 1 antikoerper, transmembrane BAX inhibitor motif containing 6 antikoerper, BI1 antikoerper, TMBIM6 antikoerper, Tmbim6 antikoerper

Hintergrund:

Synonyms: BI1, TEGT, Bax inhibitor 1, BI-1, Testis-enhanced gene transcript protein,Transmembrane BAX inhibitor motif-containing protein 6

Background: Anti-Bi-1 antibody detects human Bi-1. BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER. Anti-Bi-1 antibody is ideal for investigators involved in apoptosis research.

Gene Name: TMBIM6

Gen-ID: 7009

NCBI Accession: NP_001092046

UniProt: P55061

Pathways: Response to Water Deprivation, ER-Nucleus Signaling