Tumor Protein p73 Antikörper
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- Target Alle Tumor Protein p73 (TP73) Antikörper anzeigen
- Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Tumor Protein p73 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- Anti-p73 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-p73 from Human and Mouse based on 100% homology with the immunizing sequence. It reacts with alpha, beta, gamma and delta isoforms of mouse and human p73 as well as the dominant negative p73. Because of its reactivity pattern it may be regarded as anti-pan p73. The antibody does not cross react with p53. Cross-reactivity with Anti-p73 from other sources has not been determined.
- Immunogen
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Immunogen: p73 Antibody was produced in mice prepared by repeated immunizations with full-length human p73 protein.
Immunogen Type: Native Protein
- Klon
- 5B1288
- Isotyp
- IgG1
- Top Product
- Discover our top product TP73 Primärantikörper
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- Applikationshinweise
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Application Note: Anti-p73 Antibody is suitable for use in ChIP, IF/ICC, IP and WB. Expect a band approximately 70 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
Western Blot Dilution: 1-3 μg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 0.05 % BSA
0.05 % (w/v) Sodium Azide - Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- RT,4 °C,-20 °C
- Informationen zur Lagerung
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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- Target
- Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))
- Andere Bezeichnung
- p73 (TP73 Produkte)
- Synonyme
- P73 antikoerper, Trp73 antikoerper, TP73 antikoerper, tp73 antikoerper, Tp73 antikoerper, p73 antikoerper, TAp73 antikoerper, zp73theta antikoerper, tumor protein p73 antikoerper, transformation related protein 73 antikoerper, TP73 antikoerper, Tp73 antikoerper, tp73 antikoerper, Trp73 antikoerper
- Hintergrund
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Synonyms: P73, Tumor protein p73, p53-like transcription factor, p53-related protein
Background: Anti-p73 antibody detects human p73. p73 was identified as a long-lost cousin of tumor suppressor protein, p53. p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63 % amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression. The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections. Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein. Tumor BioMarker found p73 to be upregulated in a significant fraction of anaplastic thyroid cancers, whereas it was not detectable in normal thyroid epithelial cells nor in papillary or follicular thyroid cancer. Anti-p73 antibody is ideal for investigators involved in cell cycle protein research.
Gene Name: TP73
- Gen-ID
- 7161
- NCBI Accession
- NP_001119712
- UniProt
- O15350
- Pathways
- Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus
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