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NOXA Antikörper

Rockland 200-301-h98 PMAIP1 Reaktivität: Human WB, IHC, IF, FACS Wirt: Maus Monoclonal 114C307-1 unconjugated
Rockland
Produktnummer ABIN6655871
Hersteller Produkt- Nr.: 200-301-h98
  • Target Alle NOXA (PMAIP1) Antikörper anzeigen
    NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
    Reaktivität
    • 32
    • 4
    • 2
    Human
    Wirt
    • 26
    • 5
    • 1
    • 1
    Maus
    Klonalität
    • 19
    • 14
    Monoklonal
    Konjugat
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser NOXA Antikörper ist unkonjugiert
    Applikation
    • 12
    • 10
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
    Hersteller Produkt- Nr.
    200-301-h98
    Hersteller
    Rockland
    Verwendungszweck
    NOXA Antibody
    Kreuzreaktivität (Details)
    A BLAST analysis was used to suggest cross-reactivity with Anti-Noxa from human and mouse based on 100 % homology with the immunizing sequence.
    Aufreinigung
    Anti-Noxa Antibody was purified by Protein G chromatography.
    Immunogen
    Noxa Antibody was produced in mice prepared by repeated immunizations with the human protein Noxa.
    Klon
    114C307-1
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product PMAIP1 Primärantikörper
  • Applikationshinweise

    Immunohistochemistry_Dilution: 5 μg/mL

    Western_Blot_Dilution: 1-2 μg/mL

    Kommentare

    Anti-Noxa antibody is tested for use by WB, Flow, ICC/IF, IHC, and IHC-P. Expect a band approximately 6 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Optional[Buffer]: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 ,0.05 % (w/v) Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Haltbarkeit
    12 months
  • Ichikawa, Alves, Pfeiffer, Langa, Hernández-Santana, Suzuki, Prehn, Engel, Henshall: "Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice." in: Cell death & disease, Vol. 8, Issue 1, pp. e2556, (2017) (PubMed).

  • Target
    NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
    Andere Bezeichnung
    Noxa (PMAIP1 Produkte)
    Hintergrund

    Synonyms: NOXA, Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa

    Background: Anti-Noxa antibody detects human Noxa. Recently, a BH-3 only member of the Bcl-2 family have been identified in human and mouse and designated as Noxa (for damage). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Noxa cDNA codes for a 103-amino acid protein. The coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as, Bcl-XL and Mcl-1. Oda et al. have also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis suggesting that Noxa may represent a mediator of p53-dependent apoptosis. Anti-Noxa antibody is ideal for investigators involved in apaoptosis research.

    Gene Name: PMAIP1

    Gen-ID
    5366
    NCBI Accession
    NP_066950
    UniProt
    Q13794
    Pathways
    p53 Signalweg, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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