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Bassoon Antikörper (N-Term)

BSN Reaktivität: Human WB, FM Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6657297
  • Target Alle Bassoon (BSN) Antikörper anzeigen
    Bassoon (BSN)
    Bindungsspezifität
    • 13
    • 2
    • 1
    • 1
    N-Term
    Reaktivität
    • 24
    • 14
    • 14
    • 1
    • 1
    Human
    Wirt
    • 24
    • 3
    Kaninchen
    Klonalität
    • 24
    • 3
    Polyklonal
    Konjugat
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Bassoon Antikörper ist unkonjugiert
    Applikation
    • 19
    • 18
    • 4
    • 4
    • 3
    • 2
    Western Blotting (WB), Fluorescence Microscopy (FM)
    Kreuzreaktivität
    Human, Maus, Ratte (Rattus)
    Aufreinigung
    Anti-Bassoon Antibody was purified by affinity chromatography. A BLAST analysis was used to suggest cross-reactivity with Bassoon from Human, Mouse, and Rat based on 100% homology with the immunizing sequence. Other species not yet tested. Cross-reactivity with Bassoon from other sources has not been determined. Neuroscience research.
    Immunogen

    Immunogen: Bassoon Antibody was produced from whole rabbit serum prepared by repeated immunizations with a N-terminal his-tagged fusion protein.

    Immunogen Type: Recombinant Protein

    Isotyp
    IgG
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  • Applikationshinweise

    Application Note: Anti-Bassoon Antibody is suitable for use in WB and IHC. Expect a band approximately ~420 kDa on specific lysates corresponding to the molecular mass of Bassoon. Multiple isoforms can be detected. Specific conditions for reactivity should be optimized by the end user. Product provided in PBS pH 7.4.

    Western Blot Dilution: 1:1000

    IF Microscopy Dilution: 1:400

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer

    Buffer:

    Stabilizer: 50 % (v/v) Glycerol

    0.09 % (w/v) Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    RT,4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Target
    Bassoon (BSN)
    Andere Bezeichnung
    Bassoon (BSN Produkte)
    Synonyme
    Znf231 antikoerper, ZNF231 antikoerper, bassoon antikoerper, bassoon (presynaptic cytomatrix protein) antikoerper, bassoon presynaptic cytomatrix protein antikoerper, Bsn antikoerper, BSN antikoerper
    Hintergrund

    Synonyms: BSN, ZNF231, Neuronal double zine finger protein, protein bassoon

    Background: Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors.

    Gene Name: BSN

    Gen-ID
    8927
    NCBI Accession
    NP_003449
    UniProt
    Q9UPA5
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