GRIA2 Antikörper (C-Term)

Produktnummer ABIN6658073

Hersteller Produkt- Nr.: 200-301-f34

Produktdetails anti-GRIA2 Antikörper

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Bindungsspezifität: C-Term

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GRIA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Hersteller Produkt- Nr.: 200-301-f34

Hersteller: Rockland

Verwendungszweck: GluR2 Antibody

Kreuzreaktivität (Details): A BLAST analysis was used to suggest cross-reactivity with GluR2 from Human, Mouse, and Rat based on 100 % homology with the immunizing sequence.

Aufreinigung: Anti-GluR2 Antibody was purified by Protein G chromatography.

Sterilität: Sterile filtered

Immunogen: GluR2 Antibody was produced in mice by repeated immunizations with a fusion protein corresponding to a cytoplasmic C-terminus region of rat GluR2.

Klon: S21-32

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Immunoprecipitation_Dilution: User Optimized

Immunohistochemistry_Dilution: 0.1-1.0 μg/mL

IF_Microscopy_Dilution: 1.0-10 μg/mL

Western_Blot_Dilution: 1 μg/mL

Kommentare:

Anti-GluR2 Antibody is tested for use in WB and IHC, and is suitable in IP and Immuno-gold EM. Expect a band approximately ~90kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu GRIA2

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Andere Bezeichnung: GluR2 (GRIA2 Produkte)

Hintergrund:

Synonyms: Glutamate receptor 2, GluR-2, GLUR2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2

Background: The AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the CNS. AMPARs are composed of four types of subunits, designated as GluR1, GluR2, GluR3 and GluR4, which combine to form tetramers. GluR2 is possibly the most important AMPA receptor subunit, responsible for AMPA receptor rectifying properties, control of ion flow and in particular, the influx of calcium. The majority of GluR2 in the CNS is expressed in the GluR2 form, containing a critical arginine residue in the transmembrane region 2 domain, thereby rendering native AMPA receptors impermeable to calcium.

Gene Name: GRIA2

Gen-ID: 29627

UniProt: P19491

Pathways: PI3K-Akt Signalweg